RFA of thyroid nodules is a safe, minimally invasive technique effective for treatment of benign thyroid nodules, including toxic nodules. Its use in primary small papillary thyroid cancers will most likely to expand. As we are moving forward toward the care of the patient with personalized approach, RFA will be an important tool for select cases of thyroid nodules. A careful selection of specific benign and certain malignant nodules in well selected patients will ensure a therapeutic response without complications and risk associated with surgical approaches. However, further research with larger sample sizes and longer follow-up periods is necessary to confirm its longterm effectiveness and refine its role in the broader management of thyroid nodules.