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nsPFA is the abreviation for Nanosecond Pulsed Field Ablation (nsPFA)

It is also referred to as CellFX.

It is indicated for ablation of soft tissue in percutaneous, and intraoperative surgical procedures, such as thyroid nodules.

nsPFA creates a high volutage DC electric field in very short-duration pulses. It penetrates the cell membrane and disrupts internal cellular function, leading to regulated cell death. nsPFA eliminates targeted cells while sparing adjacent noncellular tissue. It is a nonthermal treatment because the total energy delivered is low.

Unlike thermal (heat/cold) modalities, nsPFA directly impacts cellular structures while sparing noncellular tissue

Non-thermal Nanosecond Pulsed Field Ablation (nsPFA) technology delivers nanosecond (billionth of a second) duration pulses of electrical energy.

High speed nanosecond energy pulses penetrate the cell membrane and disrupt internal cellular function, resulting in natural cellular removal.

Unlike thermal (heat/cold) modalities, nsPFA directly effects cellular structures while preserving noncellular tissues including skin, vessels and nerves.

Transcript of video

The nPulse system by Pulse Biosciences is the only system offering proprietary nanosecond pulse field ablation technology, which non-thermally eliminates cells while sparing adjacent non-cellular tissue, such as collagen and extracellular matrix. nPulse technology utilizes ultra fast, nanosecond duration high-intensity energy pulses to alter cellular function.

These energy pulses create nanopores in the lipid membranes of cells, allowing ions to move across both the outer cell membrane and intracellular organelle membranes. This triggers a cascade of homeostatic disturbances in vital cellular functions and ultimately induces regulated cell death, such as apoptosis.

The cell specific nature of nanosecond pulse energy, leaves acellular tissue unaffected, minimizing risk of damage to surrounding vital structures. nsPFA energy uniquely targets intracellular organelles to disrupt cellular homeostasis and initiate regulated cell death. Outer cell membranes are left intact.

Microsecond pulses permanently damage these membranes, allowing leakage of intracellular components leading to a necrotic inflammatory response.

The nPulse system represents a leap forward in cellular specific energy based ablation technology across multiple medical device domains. The nPulse vibrance percutaneous electrode delivers nsPFA energy to offer a minimally invasive solution for ablation of soft tissues. Bipolar electrodes deliver nsPFA energy.

To induce regulated cell death, eliminating targeted cells without causing thermal damage to critical surrounding structures, such as nerves and vessels in a fast, safe, and streamlined procedure, the impulse system is engineered to address diverse medical needs and is poised for future expansion into various new medical applications through continuous innovation.

Thyroid Nodule CellFX nsPFA treatment is SAFE:

CellFX technology only affects cellular soft tissue, like nodules, increasing safety around other critical structures like nerves, vessels and skin.

Thyroid Nodule CellFX nsPFA treatment is FAST:

CellFX procedures typically take only a few minutes, varying based on soft tissue nodule size.

Thyroid Nodule CellFX nsPFA treatment enables NATURAL HEALING:

CellFX technology promotes a rapid, natural process for clearing unwanted cellular tissue resulting in a gentle, comfortable post-procedure experience.

Benefits of the CellFX Procedure include:

Precision Procedure

CellFX specifically targets only the cells of your benign soft tissue nodule, sparing nearby healthy tissue and nearby critical structures.

Minimal Discomfort

CellFX is a minimally invasive procedure with less pain and discomfort compared to traditional methods such as surgery. Most patients experience minimal discomfort during and after the procedure.

Quick and Efficient

Procedures typically last only minutes once started. Most patients can return to daily activities with little to no downtime. However, the total visit time may vary depending on the size and location of the thyroid nodule being treated.

Minimally Invasive

CellFX technology minimizes scarring and preserves the appearance of the treated area with only small needle puncture through the skin.

Short Recovery

Recovery from a CellFX procedure are generally short, typically within a few days. You may experience some redness or swelling at the procedure site, which typically resolves within a few days. Most patients can resume their normal activities almost immediately after the procedure.