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2025 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis

2025 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis

These comprehensive clinical guidelines from the American Thyroid Association (ATA) provide evidence‑based recommendations for the diagnosis and management of hyperthyroidism and other causes of thyrotoxicosis. The document reviews the epidemiology, pathophysiology, diagnostic evaluation, and therapeutic options for conditions including Graves’ disease, toxic multinodular goiter, toxic adenoma, thyroiditis, and iatrogenic thyrotoxicosis. It evaluates antithyroid medications, radioactive iodine therapy, and thyroidectomy, outlining indications, contraindications, and comparative outcomes. The guidelines also address special populations such as pregnant patients, children, and individuals with severe or refractory disease. This publication remains a foundational reference for clinicians managing hyperthyroidism and provides a framework for consistent, evidence‑based care.

The 2016 ATA Guidelines represent one of the most authoritative and widely used clinical frameworks for diagnosing and managing hyperthyroidism and related causes of thyrotoxicosis. Developed by a multidisciplinary panel, the guidelines synthesize current evidence to support standardized, safe, and effective care. The document outlines recommended diagnostic pathways, including the use of thyroid function tests, antibody assays, radioactive iodine uptake, and imaging. For Graves’ disease, the guidelines compare the three primary treatment modalities—antithyroid medications, radioactive iodine ablation, and thyroidectomy—detailing indications, expected outcomes, and potential complications for each.

Citation

Ross DS, Burch HB, Cooper DS, et al. 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis. Thyroid. 2016;26(10):1343-1421. doi:10.1089/thy.2016.0229

Conclusion

American Thyroid Association (ATA), Hyperthyroidism, Thyrotoxicosis, Graves’ disease, Antithyroid drugs, Radioactive iodine, Thyroidectomy, Toxic multinodular goiter, Clinical guidelines, Endocrinology

Key Words

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