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Comparing the Health-Related Quality of Life at Two Years After Successful Treatment of Relapsed Graves' Disease With Radiofrequency Ablation, Surgery, or Radioiodine

Conventional definitive treatments of relapsed Graves' disease (GD) include surgery and radioiodine therapy (RAI). Recently, radiofrequency ablation (RFA) has emerged as a potential novel treatment option. This study compared the health-related quality of life (HRQOL) at 2 years after treatment of relapsed GD with RFA, surgery, and RAI.

Fung MHM, Liu X, Lui DTW, Luk Y, Wong CKH, Hin Lang BH. Comparing the Health-Related Quality of Life at Two Years After Successful Treatment of Relapsed Graves' Disease With Radiofrequency Ablation, Surgery, or Radioiodine. World J Surg. 2025;49(11):3142-3151. doi:10.1002/wjs.70035

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At 2 years after treatment of relapsed GD, single-session RFA achieved significantly better outcomes in terms of less depressive symptoms and at least comparable outcomes in most HRQOL domains when compared to surgery and RAI, when a disease-specific questionnaire (ThyPRO-39) was used. Comparable outcomes from generic HRQOL questionnaires were noted across RFA, surgery, and RAI.

Graves' disease (GD), radioiodine therapy (RAI), radiofrequency ablation (RFA), total thyroidectomy, surgery

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