Based on the existing literature, the greatest shift in the future routine management of benign thyroid nodules will probably be determined by the availability of nonsurgical, minimally invasive techniques, such as RFA. This technique has shown the potential to help in the daily management of thyroid nodules, particularly when they are single, cold, and symptomatic, where it has been proven safe and effective. In our view, RFA does not overlap with the conventional and established treatments for thyroid nodules, namely surgery and radioiodine, but it is complementary to them. RFA could in fact represent the solution for a need that has remained unanswered for years, helping those patients that perceive their nodule as s something too small to be conventionally treated (or which cannot be conventionally treated), but too big to keep with the simple clinical follow-up.