https://www.thyroidnoduletreatment.center/es/research/scarless-procedures%2C-including-rfa-and-toetva%2C-for-the-treatment-of-unilateral-benign-tns-are-effective-with-few-but-unique-complications.-toetva-achieves-higher-cosmetic-success-rates-and-patient-satisfaction.-the-cost-of-a-single-treatment-with-rfa-is-lower%2C-but-the-cost-of-retreatment-must-be-considered.-in-addition%2C-clinicians-should-note-that-benign-cytology-before-treatment-may-be-accompanied-by-malignant-tumours. 2026-03-18 https://www.thyroidnoduletreatment.center/es/research/in-rfa-for-thyroid-nodules%2C-a-stable-treatment-efficacy-is-achieved-after-20-treatments%2C-with-a-median-vrr-of-70.8%25.-baseline-nodule-volume%2C-energy-delivered%2C-and-prolonged-follow-up-6-months-after-treatment-may-not-be-clinically-relevant-to-predict-treatment-success. 2026-03-18 https://www.thyroidnoduletreatment.center/es/research/single-session-rfa-may-be-sufficient-for-achieving-adequate-volume-reduction-during-long-term-follow-up-for-small-volume-benign-thyroid-nodules.-a-high-vrr-was-maintained-regardless-of-the-nodular-component%2C-location%2C-demographic-factors%2C-or-vascularity-type.-however%2C-large-volume-nodules-may-require-multiple-rfa-sessions-to-achieve-a-comparable-vrr. 2026-03-18 https://www.thyroidnoduletreatment.center/es/research/in-patients-with-hyperthyroidism%2C-surgery-was-associated-with-significantly-decreased-risks-of-all-cause-mortality-and-cardiovascular-mortality-compared-with-atd-and-rai.-risks-of-mace-and-cancer-mortality-did-not-differ-by-type-of-hyperthyroidism-treatment.-however%2C-these-findings-should-be-interpreted-with-caution-due-to-inherent-methodological-limitations-of-observational-studies%2C-including%2C-but-not-limited-to-heterogeneity-and-potential-selection-bias. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/the-treatment-of-gd-is-seeing-the-shift-from-ablative-therapy-to-atds%2C-with-data-indicating-this-to-be-the-dominant-first-therapy-in-most-regions-worldwide.-the-likelihood-of-remission-can-be-more-clearly-defined-with-the-use-of-great-and-great%2B-scores.-if-remission-is-not-likely%2C-that-is-no-longer-deterring-patients-and-clinicians-from-continuing-atd-therapy-long-term%2C-as-the-benefit-of-preserving-the-thyroid-and-endogenous-thyroid-hormone-production-is-becoming-increasingly-apparent.-we-are-witnessing%2C-with-high-hope%2C-the-interest-of-the-research-community-shifting-toward-manipulating-the-autoimmune-response%2C-either-through-inducing-tolerance-to-the-tshr%2C-eliminating-the-trab%2C-or-blocking-the-tshr-at-the-extracellular-or-the-transmembrane-domain.-these-approaches-will-hopefully-allow-a-rapid-resolution-of-clinical-hyperthyroidism-and-its-associated-goiter%2C-while-also-positively-impacting-ted-and-ptd%2C-if-present-simultaneously.-the-added-benefit-in-patients-having-isolated-thyroid-autoimmunity-will-be-the-expected-decrease-or-elimination-of-the-risk-of-ted%2C-ptd-and-fetal%2Fneonatal-thyrotoxicosis.-the-new-agents-will-nevertheless-require-adjustments-to-our-disease-monitoring-practices-and-possibly-utilization-of-a-%E2%80%98block-and-replace%E2%80%99-principle-with-some-of-these-therapies.-in-addition%2C-we-hope-to-see-a-more-individualized-approach-to-thyroid-level-testing-and-atd-dose-adjustments-through-the-utilization-of-technology-and-biomarkers-already-within-the-reach-of-today%E2%80%99s-wearable-devices. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/our-data-showed-that-thyroidectomy-was-associated-with-lower-long-term-risks-than-atd-and-rai-in-all-cause-mortality%2C-cvd%2C-af%2C-psychological-disease%2C-diabetes%2C-and-hypertension.-similarly%2C-rai-treatment-was-associated-with-reduced-risks-of-all-cause-mortality%2C-cvd%2C-af%2C-and-psychological-disease-than-atd-therapy.-the-surgery-group-also-incurred-the-lowest-10-year-accumulative-healthcare-cost-due-to-the-lower-relapse-rate.-there-appeared-to-be-an-association-between-number-of-rais-administered-and-long-term-mortality-risk.-this-study-lends-support-to-an-increased-role-of-surgery-as-a-first-line-treatment-in-gd. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/at-2-years-after-treatment-of-relapsed-gd%2C-single-session-rfa-achieved-significantly-better-outcomes-in-terms-of-less-depressive-symptoms-and-at-least-comparable-outcomes-in-most-hrqol-domains-when-compared-to-surgery-and-rai%2C-when-a-disease-specific-questionnaire-(thypro-39)-was-used.-comparable-outcomes-from-generic-hrqol-questionnaires-were-noted-across-rfa%2C-surgery%2C-and-rai. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/in-well-selected-patients%2C-single-session-rfa-of-the-thyroid-gland-may-be-a-potential-treatment-for-patients-with-persistent%2Frelapsed-gd.-it-is-a-safe-and-well-tolerated-ambulatory-procedure. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/finally%2C-our-study-showed-that-rfa-was-well-tolerated-and-safe-in-our-cohort.-all-patients-could-be-discharged-on-the-same-day%2C-and-none-suffered-from-vcp%2C-skin-burn%2C-hematoma%2C-or-severe-thyrotoxicosis.-we-find-adding-sedation-beneficial-to-patient-experience-and-using-intraoperative-laryngeal-ultrasonography-to-monitor-vocal-cord-function-highly-reassuring-for-this-bilateral-procedure.-single-session-rfa-of-the-thyroid-gland-led-to-disease-remission-in-a-highly-selected-group-of-patients-with-relapsed-gd.-smaller-total-thyroid-volume-may-be-a-favorable-factor-associated-with-disease-remission-after-rfa.-the-durability-of-rfa-treatment-and-the-results-of-this-study-need-to-be-confirmed-with-a-long-term-clinical-trial. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/this-first-in-human-study-supports-the-initial-safety%2Fefficacy-profile-of-the-nspfa-electrode-system-in-treating-benign-thyroid-nodules.-the-minimally-invasive-and-nonthermal-nature-of-nspfa-energy-has-the-potential-to-reduce-risk-of-major-complications-in-treatment-of-benign-thyroid-nodules-as-compared-with-thyroidectomy-or-thermal-ablation-and-to-improve-healing-through-rapid-reduction-ofablated-areas-and-lack-of-postprocedural-scarring.-the-rapid-rate-of-shrinkage-of-the-treated-nodules-and-absence-of-any-adverse-effects-of-the-treatment-lead-us-to-conclude-that-this-new-modality-is-feasible-and-holds-promise-to-improve-patient-outcomes.-the-treated-regions-are-soft-to-the-touch-and-lack-any-residual-indurated-tissue.-we-believe-the-results-of-this-feasibility-study-show-that-nspfa-offers-a-new-approach-that-is-feasible-and-promising-for-further-study.-this-treatment-is-safe-and-provides-a-faster-rate-of-thyroid-nodule-shrinkage-than-competing-technologies. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/the-2016-ata-guidelines-represent-one-of-the-most-authoritative-and-widely-used-clinical-frameworks-for-diagnosing-and-managing-hyperthyroidism-and-related-causes-of-thyrotoxicosis.-developed-by-a-multidisciplinary-panel%2C-the-guidelines-synthesize-current-evidence-to-support-standardized%2C-safe%2C-and-effective-care.-the-document-outlines-recommended-diagnostic-pathways%2C-including-the-use-of-thyroid-function-tests%2C-antibody-assays%2C-radioactive-iodine-uptake%2C-and-imaging.-for-graves%E2%80%99-disease%2C-the-guidelines-compare-the-three-primary-treatment-modalities%E2%80%94antithyroid-medications%2C-radioactive-iodine-ablation%2C-and-thyroidectomy%E2%80%94detailing-indications%2C-expected-outcomes%2C-and-potential-complications-for-each. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/in-this-1912-lancet-article%2C-thomas-peel-dunhill-presents-his-clinical-experience-performing-partial-thyroidectomy-under-local-anesthesia%2C-focusing-on-its-use-in-patients-with-exophthalmic-goiter.-at-the-time%2C-thyroid-surgery-carried-substantial-risk%2C-particularly-in-hyperthyroid-patients-whose-cardiovascular-instability-made-general-anesthesia-hazardous.-dunhill-argues-that-local-anesthesia-reduces-operative-stress%2C-improves-intraoperative-safety%2C-and-allows-for-more-controlled-resection.-the-paper-outlines-his-operative-technique%2C-including-careful-dissection%2C-limited-gland-removal%2C-and-strategies-to-avoid-hemorrhage-and-postoperative-thyroid-crisis.-dunhill%E2%80%99s-emphasis-on-conservative%2C-staged%2C-or-unilateral-subtotal-resection-would-later-influence-the-development-of-the-%E2%80%9Cdunhill-procedure%2C%E2%80%9D-a-technique-that-significantly-reduced-mortality-in-the-surgical-treatment-of-graves%E2%80%99-disease.-this-publication-is-historically-significant-because-it-documents-one-of-the-earliest-systematic-attempts-to-make-thyroid-surgery-safer-through-both-anesthetic-choice-and-operative-refinement.-it-provides-insight-into-pre%E2%80%91pharmacologic-management-of-hyperthyroidism-and-the-evolution-of-surgical-standards-that-shaped-modern-endocrine-surgery. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/this-article-provides-a-comprehensive-historical-analysis-of-thomas-peel-dunhill%2C-an-influential-but-often-under%E2%80%91recognized-pioneer-in-thyroid-surgery.-dunhill%E2%80%99s-major-contribution-was-the-refinement-of-unilateral-subtotal-thyroidectomy-%E2%80%94-later-known-as-the-%E2%80%9Cdunhill-procedure%E2%80%9D-%E2%80%94-which-dramatically-improved-safety-in-the-surgical-treatment-of-graves%E2%80%99-disease-and-toxic-goiter-at-a-time-when-operative-mortality-was-high.-the-paper-details-dunhill%E2%80%99s-training%2C-his-early-work-in-australia%2C-and-his-later-practice-in-london%2C-where-he-became-known-for-meticulous-technique-and-a-strong-emphasis-on-reducing-surgical-risk.-vellar-documents-dunhill%E2%80%99s-interactions-with-leading-surgeons-of-the-era%2C-including-theodor-kocher%2C-and-explores-how-professional-politics%2C-geography%2C-and-publication-patterns-contributed-to-dunhill%E2%80%99s-relative-obscurity-despite-his-innovations.-the-article-is-valuable-for-understanding-the-evolution-of-thyroid-surgery%2C-the-development-of-safer-operative-strategies-for-hyperthyroidism%2C-and-the-historical-context-that-shaped-modern-endocrine-surgery.-it-also-provides-insight-into-the-early-management-of-graves%E2%80%99-disease-before-the-advent-of-antithyroid-medications%2C-radioactive-iodine%2C-and-minimally-invasive-ablation-techniques. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/mwa%2C-as-a-minimally-invasive-technique%2C-has-demonstrated-safety-and-efficacy-in-the-treatment-of-btn%2C-low-risk-ptmc%2C-and-lymph-node-metastases-(lnm).-mwa-is-associated-with-faster-treatment-times-and-the-ability-to-create-a-larger%2C-more-uniform-ablation-zone%2C-making-it-particularly-advantageous-for-nodules-located-near-blood-vessels.-nonetheless%2C-additional-comprehensive-studies-with-long-term-follow-up-are-necessary-in-the-latin-american-population-to-further-validate-and-expand-the-application-of-this-therapy%2C-particularly-in-cases-of-ptmc-and-lnm. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/mwa-is-a-newly-developed-minimally-invasive-technique-for-treating-cytologically-benign-thyroid-nodules.-it-may-become-a-safe-and-effective-alternative-to-surgery.-it-can-achieve-shrinkage-of-nodule-size-and-relief-of-clinical-symptoms.-though-side-effects-and-complications-are-few%2C-the-operators-still-should-be-aware-of-the-significance-and-the-available-preventative-techniques.-further-studies-are-needed-to-define-the-role-of-the-procedure-and-improve-this-technique. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/microwave-ablation-for-the-treatment-of-btns-is-effective-and-safe-and-is-expected-to-be-a-potential-first-line-treatment.-the-thyroid-function-of-all-148-patients-was-reviewed-48-months-after-mwa%2C-showing-no-significant-variation-compared-with-that-before-mwa.-this-shows-that-mwa-does-not-cause-hypothyroidism-in-patients%2C-which-is-a-very-important-advantage-of-mwa-for-btns.-in-conclusion%2C-over-48-month-follow-up%2C-mwa-for-the-treatment-of-btns-is-effective-and-safe-and-is-expected-to-be-a-potential-first-line-treatment. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/microwave-ablation-(mwa)-is-a-new%2C-promising-technique-among-the-minimally-invasive-treatments-of-thyroid-nodules.-actually%2C-the-larger-diameter-of-mw-antenna-seems-to-be-the-major-limiting-factor-in-the-use-of-this-technique.-more-studies-are-necessary-to-evaluate-feasibility%2C-safety-and-efficacy-of-the-procedure. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/rfa-of-thyroid-nodules-is-a-safe%2C-minimally-invasive-technique-effective-for-treatment-of-benign-thyroid-nodules%2C-including-toxic-nodules.-its-use-in-primary-small-papillary-thyroid-cancers-will-most-likely-to-expand.-as-we-are-moving-forward-toward-the-care-of-the-patient-with-personalized-approach%2C-rfa-will-be-an-important-tool-for-select-cases-of-thyroid-nodules.-a-careful-selection-of-specific-benign-and-certain-malignant-nodules-in-well-selected-patients-will-ensure-a-therapeutic-response-without-complications-and-risk-associated-with-surgical-approaches.-however%2C-further-research-with-larger-sample-sizes-and-longer-follow-up-periods-is-necessary-to-confirm-its-longterm-effectiveness-and-refine-its-role-in-the-broader-management-of-thyroid-nodules. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/overall%2C-our-work-demonstrated-similar-success%2C-regrowth%2C-and-complication-ratesbetween-benign-and-indeterminate-thyroid-nodule-rfa.-moving-forward%2C-studies-of-largersample-sizes-and-longer-follow-up-duration-could-realistically-posit-rfa-as-a-potentialtreatment-option-for-indeterminate-thyroid-nodules. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/our-work-found-no-differences-in-outcomes-or-safety-in-patients-undergoing-thyroidectomy-with-or-without-previous-radiofrequency-ablation-treatment%2C-potentiating-the-post-radiofrequency-ablation-thyroidectomy-group-as-a-safe-management-option.-accordingly%2C-this-may-reassure-both-clinicians-and-patients-of-the-safety-of-radiofrequency-ablation-in-treating-patients-with-thyroid-nodules.-richard-harding-(phoenix%2C-az)%3A-is-your-treatment-failure-rate-associated-with-the-amount-of-energy-delivered-to-those-nodules%3F-how-many-joules-were-delivered-to-the-nodules-that-failed-rfa-or-had-regrowth%3F-peter-issa%3A-unfortunately%2C-we-do-not-have-the-power-or-the-joules-delivered-per-nodule%2C-so-we-cannot-make-any-conclusions-on-that.-nonetheless%2C-we-have-been-collecting-energy-delivered-per-nodule-data-prospectively-for-the-past-few-months 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/to-our-knowledge%2C-this-is-the-largest-north-american-cohort-of-patients-with-benign-thyroid-nodules-treated-with-radiofrequency-ablation.-overall%2C-radiofrequency-ablation-was-an-effective-treatment-option-with-a-low-risk-of-procedural-complications.-large-volume-nodules-(%3E20-ml)-may-be-associated-with-a-lower-rate-of-successful-reduction-with-radiofrequency-ablation-treatment. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/rfa-is-safe-and-effective-for-treating-benign-thyroid-nodules%2C-with-a-high-vrr-at-long-term-follow-up.-regular-follow-up-after-initial-success-is-warranted-because-of-the-possibility-of-regrowth-of-ablated-nodules-and-the-need-for-delayed-surgery-in-some-patients. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/rta-induced-a-marked-tn-volume-shrinkage-resulting-in-parallel-improvement-of-pressure-symptoms.-in-most-patients-with-toxic-tns%2C-hyperthyroidism-significantly-improved-as-well.-rta-may-represent-a-valid-therapeutic-approach-in-patients-with-tns-not-receiving-conventional-treatments. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/a-recent-systematic-review-argued-the-superiority-of-rfa-compared-to-laser-(la)-in-reducing-benign-solid-tn-volume-for-nodules-with-volumes-%3C15ml.-in-summary%2C-the-rfa-technique-seems-to-share-similar-indications-to-la.-in-conclusion%2C-rfa-can-be-considered-a-viable-alternative-to-classic-thyroid-surgery. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/alternative-treatments-recently%2C-image-guided-minimally-invasive-techniques-(percutaneous-ethanol-ablation%2C-radiofrequency%2C-laser%2C-microwave-ablation%2C-and-high-intensity-focused-ultrasound)-have-been-proposed-and-may-be-considered-for-treating-clinically-relevant-benign-thyroid-nodules.-radioiodine-therapy-should-be-considered-for-patients-with-hyperfunctioning-nodules-whose-biochemical-testing-shows-hyperthyroidism%2C-but-surgery-is-also-a-reasonable-approach-in-patients-with-large-(%3E-4-cm)-nodules.-most-thyroid-nodules-are-benign.-a-diagnostic-approach-that-uses-ultrasound-and%2C-when-indicated%2C-fine-needle-aspiration-biopsy-and-molecular-testing%2C-facilitates-a-personalized%2C-risk-based-protocol-that-promotes-high-quality-care-and-minimizes-cost-and-unnecessary-testing. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/surgery-and-radioiodine-treatment-remain-the-conventional-and-established-treatments-for-nodular-goiters.-however%2C-the-new-image-guided-minimally-invasive-approaches-appear-safe-and-effective-alternatives-when-used-appropriately-and-by-trained-professionals-to-treat-symptomatic-or-enlarging-thyroid-masses. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/thyroid-thermal-ablation-is-superior-to-conventional-thyroidectomy-in-terms-of-patients-satisfaction%2C-post-operative-quality-of-life%2C-and-shorter-hospital-stay-but-takes-longer-to-achieve-btns-volume-reduction.-the-complication-rates-between-the-two-groups-were-similar. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/this-meta-analysis-showed-that-both-rfa-and-laser-ablation-are-able-to-obtain-a-significant-volume-reduction-in-bnfstns.-a-significant-volume-reduction-is-already-evident-at-6-months-after-thermal-ablation-and-results-are-stable-over-the-time. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/rfa-was-found-to-be-safe-for-the-treatment-of-benign-thyroid-nodules-and-recurrent-thyroid-cancers. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/rfa-seems-to-be-an-effective-and-safe-alternative-to-surgery-in-high-risk-surgical-patients-with-thyroid-cancers-and-for-selected-btns.-additional-trials-with-longer-follow-up-in-north-american-patients-are-needed-to-validate-its-full-role-in-the-armamentarium-of-thyroidologists. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/the-devices-and-techniques-for-thyroid-rfa-continue-to-evolve.-understanding-the-basic-and-advanced-rfa-techniques%2C-and-selecting-the-optimal-treatment-strategy%2C-are-critical-to-optimize-treatment-efficacy-and-patient-safety. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/this-multicenter-study-validated-the-efficacy-and-safety-of-rf-ablation-for-treating-aftn%3B-rf-ablation-can-be-considered-an-alternative-to-surgery-or-radioiodine-therapy. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/in-conclusion%2C-our-comparative-study-suggests-that-rfa-represents-an-effective-alternative-to-surgery%2C-which-is-very-expensive-and-occasionally-unnecessary%2C-for-the-treatment-of-benign-thyroid-nodules-causing-local-symptoms-or-cosmetic-concerns.-nevertheless%2C-this-study-does-not-dismiss-surgery%2C-which%2C-on-the-contrary%2C-is-more-effective-than-one-rfa-session-for-treating-nodules-with-an-initial-volume-greater-than-35%E2%80%89ml-as-well-as-for-autonomously-functioning-nodules.-since-rfa-does-not-allow-for-final-pathology%2C-patients-should-undergo-two-ultrasonographic-guided-fnab-prior-to-the-procedure-and-should-be-followed-at-least-yearly-for-five-years. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/the-assignment-of-specific-cpt-codes-signifies-acceptance-of-thyroid-rfa-as-a-standard-medical-procedure%2C-potentially-including-its-adoption. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/rfa-is-a-safe-procedure-when-performed-by-experienced-operators.-previous-guidelines-and-studies%2C-including-meta-analyses%2C-have-shown-that-rfa-is-a-safe-procedure-for-the-treatment-of-benign-thyroid-nodules-and-has-a-low-incidence-of-complications.%5B10%2C31%5D-the-overall-complication-rate-was-reported-as-2.11%25-(95%25-confidence-interval-%5Bci%5D%2C-1.15%E2%80%933.06)-and-the-major-complication-rate-was-1.27%25-(95%25-ci%2C-0.81%E2%80%931.73).%5B10%5D-previous-studies-have-shown-that-rfa-performed-by-trained-radiologists%2C-using-a-unified-protocol-and-similar-devices%2C-is-safe-for-treating-benign-thyroid-nodules.-they-defined-an-experienced-operator-as-one-who-has-successfully-completed-%3E50-thyroid-rfas.%5B12%5D-these-are-the-first-thyroid-rfa-guidelines-developed-by-an-international-academic-society.-they-are-based-on-an-analysis-of-the-similarities-and-differences-among-five-guidelines-from-different-countries-and-the-expert-opinion-of-the-acta-taskforce-members.-unresolved-issues-in-these-guidelines-require-further-evaluation-and-discussion. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/the-value-of-our-present-findings-lies-in-validating-the-generalizability-of-rf-ablation-for-nonfunctioning-benign-thyroid-nodules-in-a-prospective-large-population-multicenter-study.-additionally%2C-trained-operators%2C-unified-treatment-protocols%2C-and-similar-devices-were-used-in-our-current-investigation.-although-the-efficacy-of-thyroid-rf-ablation-has-been-suggested-in-many-previous-reports%2C-such-as-retrospective-studies-(5%2C6)%2C-randomized-controlled-trials-(9%2C12%2C14%2C23%2C24)%2C-review-articles-(4%2C25%2C26)%2C-well-as-one-systematic-review-and-one-meta-analysis-each-(3%2C27)%2C-the-generalizability-of-rf-ablation-has-not-been-well-established.-the-ksthr-has-been-organizing-a-thyroid-rf-training-program-since-2007-(17).-for-our-study%2C-we-invited-radiologists-who-had-undertaken-that-training-program-and-had-experience-with-more-than-50-cases-of-thyroid-rf-ablation.-a-previous-study-(17)-revealed-that-patients-treated-by-experienced-radiologists-showed-fewer-complications-than-less-experienced-radiologists-(%3C-50-cases).-to-date%2C-there-is-no-report-on-the-learning-curve-for-the-operators-in-rf-ablation-of-thyroid-lesions%3B-however%2C-some-studies-suggest-that-experiences-with-more-than-50-cases-could-represent-the-cut-off-number-to-indicate-a-high-success-rate-for-the-procedure.-our-study-also-used-comparable-devices%2C-namely-cool-tip-rf-systems-with-thyroid-dedicated-electrodes-(straight-type-modified-internally-cooled-electrodes)-(28).-additionally%2C-we-employed-a-similar-method-that-involved-a-transisthmic-approach-and-the-moving-shot-technique-(21).-overall%2C-the-trained-operators-could-achieve-effective-and-safe-results. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/many-studies-have-demonstrated-the-efficacy-of-rfa-for-redu%02cing-the-volume-of-benign-nodules.-a-meta-analysis-by-ha-et-al-showed-a-pooled-volume-reduction-of-76.1%25-at-6-months-%5B11%5D.-long-term-studies-demonstrated-rapid-volume-reduction-at-12-months%2C-a-plateau-from-12-to-36-months%2C-and-further-volume-reduction-after-36-months-%5B12%5D.-a-meta-analysis-of-long-term-outcomes-reported-a-pooled-volume-reduction-of-80.3%25-at-3-years.-the-overall-complication-rate-was-low-at-4.6%25-with-1.3%25-major-complications%2C-including-voice-change%2C-laryngeal-nerve-injury%2C-and-brachial-nerve-injury-%5B12%5D.-generally%2C-rfa-is-most-effective-for-smaller-nodules-(vol%02umes-less-than-10-ml)-with-larger-nodules-requiring-more-than-1-treatment-%5B13%5D.-the-most-important-technical-parameter-associated-with-volume-reduction-is-the-total-energy-delivered-%5B14%5D.-compared-with-surgery%2C-rfa-is-associated-with-fewer-complications%2C-better-health-related-quality-of-life%2C-and-preservation-of-thyroid-function-%5B17%2C-44%2C-45%5D.-however%2C-it-can-take-longer-to-achieve-the-desired-volume-reduction.-a-meta-analysis-comparing-thermal-ablation-with-surgery-found-no-difference-in-symptom-improvement-but-significantly-lower-incidence-of-pain%2C-hoarseness%2C-and-hypothyroidism%2C-better-cos%02metic-outcomes%2C-and-shorter-hospitalization-with-thermal-ablation-%5B46%5D.-in-a-telephone-survey-of-126-patients-treated-with-rfa-and-84-patient-treated-with-surgery%2C-there-was-no-difference-in-the-overall-satisfaction%2C-but-more-patients-were-fully-satisfied-with-the-resolution-of-nodule-related-symptoms-in-the-surgery-group-(96%25-vs-81%25)-and-more-patients-were-fully-satisfied-with-the-cosmetic-results-in-the-rfa-group-(92%25-vs-69%25)-%5B15%5D. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/rfa-has-shown-excellent-efficacy-and-safety-in-the-management-of-cosmesis-related-concerns-and-pressure-symptoms-(47%2C-48%2C-54%E2%80%9361%2C-63%2C-64).-in-a-systematic-review-and-meta-analysis-of-rfa-in-benign-nodules%2C-a-pooled-proportion-of-2.38%25-for-overall-rfa-complications-was-noted-(95%25-ci%3A-1.42%E2%80%933.34%25)%2C-with-1.35%25-for-major-complications-(95%25-ci%3A-0.89%E2%80%931.81%25)-and-no-evidence-of-any-life-threatening-complications.-the-most-common-complaint-post-treatment-was-transient-or-rarely-permanent-voice-changes-(35%2F2%2C421).-nodule-rupture%2C-permanent-hypothyroidism-6-months-after-treatment%2C-and-transient-brachial-plexus-injury-was-only-found-in-one-patient-out-of-2%2C421-patients-(65).-minor-complications-included-pain-during-or-after-the-procedure-(16%2F2421)%2C-hematoma-which-disappeared-after-1%E2%80%932-weeks-(25%2F2%2C421)%2C-vomiting-(9%2F2%2C421)%2C-skin-burns-(six-patients-had-first-degree-burns-and-1-patient-had-second-degree-burn-which-recovered-after-a-month)-and-transient-thyroiditis-(one-patient-three-months-after-the-treatment)-(65).-furthermore%2C-various-studies-have-shown-that-the-volume-of-a-benign-symptomatic-thyroid-nodule-can-be-reduced-by-more-than-50%25%2C-and-up-to-75%E2%80%9397%25-in-long-term-follow-ups-(60%2C-66%2C-67).-the-american-thyroid-association-guidelines-outline-that-surgery-or-radioactive-iodine-(rai)-are-effective-for-the-treatment-of-aftn-(1%2C-3).-these-two-options-are-not-always-acceptable-for-patients-since-rai-involves-receiving-radiation-which-is-controversial-in-women-of-childbearing-age%2C-or-for-patients-reluctant-to-endure-the-long-term-risks-associated-with-radiation-(3).-additionally%2C-both-treatments-have-potential-complications-such-as-hypothyroidism.-even-with-lobectomy%2C-surgery-confers-roughly-a-30%25-chance-of-hypothyroidism%2C-which-is-generally-avoided-in-rfa-treated-patients-(10%2C-11%2C-68).-rfa-may-gain-favor-with-patients-wishing-to-avoid-developing-hypothyroidism-(55%2C-57%2C-58%2C-69%E2%80%9371).-the-success-rate-of-rfa-is-greater-when-the-volume-of-the-aftn-is-relatively-small-in-size.-cesareo-et-al.-compared-the-reduction-between-medium-sized-nodules-(18-ml)-and-smaller-sized-nodules-(5-ml)%2C-euthyroidism-was-achieved-86%25-in-small-nodules-vs.-45%25-in-medium-size-nodules-(75).-similarly%2C-cappelli-et-al.-report-a-volume-reduction-rate-of-73%25-with-tsh-normalization-in-94%25-of-patients-treated-with-rfa-with-nodules-an-average-of-7-ml-(76).-an-earlier-study-by-lim-et-al.-confirmed-that-larger-nodules-(%3E20-ml)-required-repeat-rfa-treatment-compared-with-smaller-nodules-to-achieve-a-similar-volume-reduction-in-during-4-year-follow-up-(77).-this-work-has-improved-our-understanding-of-how-to-counsel-patients-with-aftn.-rfa-offers-a-non-surgical-approach-for-patients-who-wish-to-avoid-surgery-altogether-or-are-poor-surgical-candidates. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/recent-studies-have-demonstrated-the-efficacy-and-safety-of-thermal-ablation-for-low-risk-papillary-thyroid-microcarcinoma-(ptmc)-(65%E2%80%9376)-as-well-as-for-recurrent-thyroid-cancer-where-the-risks-of-surgery-outweigh-the-benefits-or-in-patients-who-refuse-repeat-surgery-(77%E2%80%9390).-however%2C-it-should-also-be-recognized-that-rfa-for-low-risk-ptmc-must-be-considered-in-the-appropriate-context%2C-as-many-studies-demonstrate-excellent-outcomes-and-minimal-growth-with-simple-active-surveillance-in-this-patient-population.-preliminary-work-has-not-shown-benefit-for-poorly-differentiated-aggressive-tumors-such-as-anaplastic-carcinoma-(69).-for-medullary-thyroid-cancer-(mtc)%2C-surgery-remains-the-treatment-of-choice.-few-case-reports-have-demonstrated-rfa-to-be-a-safe-and-effective-option-for-early-mtc-in-patient%E2%80%99s-ineligible-for-surgery-(91)-or-for-patients-with-a-regional-recurrence-after-surgical-resection-of-their-mtc-(92).-however%2C-the-data-is-somewhat-limited-for-mtc-and-remains-controversial.-careful-evaluation-of-the-desired-nodule-is-required-before-ablation-to-ensure-a-successful-outcome-for-the-patient-and-to-avoid-delay-for-possible-surgery.-the-main-indications-include%3A-a)-cytopathology-confirmed-papillary-thyroid-carcinoma-(ptc)-without-evidence-of-aggressiveness-b)-single-ptc-without-extrathyroidal-extension-c)-no-metastatic-tumors-at-the-time-of-treatment-and-d)-ineligibility-for-surgery-(78).-the-operator-should-note-key-features-during-evaluation%2C-such-as-capsule-invasion-or-lymph-node-metastases%2C-and-whether-an-aggressive-variant-of-ptc-is-present.-these-features-should-prompt-surgery-instead-of-rfa.-currently%2C-the-italian-society-does-not-recommend-rfa-for-first-line-treatment-of-primary-thyroid-cancer%2C-however-emerging-evidence-has-shown-benefits%2C-safety-and-efficacy-for-treatment-of-low-risk-tumors-(46). 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/acr-ti-rads-borrows-from-the-american-thyroid-association-guidelines-and-defines-clinically-important-growth-as-a-20%25-increase-in-at-least-two-nodule-dimensions-and-a-minimal-increase-of-2-mm%2C-or-a-50%25-or-greater-increase-in-volume.-if-a-nodule-enlarges-to-the-point-where-it-exceeds-the-size-threshold-for-its-acr-ti-rads-level%2C-we-recommend-fna%2C-if-this-has-not-already-been-performed.-although-rapid-enlargement-is-suspicious%2C-growth-does-not-reliably-distinguish-between-benign-and-malignant-nodules.-however%2C-nodules-that-do-not-grow-substantially-over-the-course-of-5-years-(based-on-comparison-between-initial-and-5-year-sonograms)-may-be-considered-benign.-nodules-that-exhibit-an-interval-increase-in-acr-ti-rads-level-but-remain-below-the-size-threshold-for-fna-should-be-imaged-with-follow-up-us-in-1-year.-the-acr-ti-rads-risk-stratification-system-allows-practitioners-to-determine-whether-thyroid-nodules-require-biopsy%2C-follow-up%2C-or-no-further-action-based-on-their-us-appearance.-success-demands-close-cooperation-between-radiologists-and-sonographers%2C-understanding-of-the-nuances-and-pitfalls-of-feature-assignments%2C-and-attention-to-detail-in-reporting-and-making-recommendations. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/this-is-the-first-study-to-identify-a-surgeon-volume-threshold-(%3E25-total-thyroidectomies%2Fy)-that-is-associated-with-improved-patient-outcomes.-identifying-a-threshold-number-of-cases-defining-a-high-volume-thyroid-surgeon-is-important%2C-as-it-has-implications-for-quality-improvement%2C-criteria-for-referral-and-reimbursement%2C-and-surgical-education.-establishing-a-definition-for-a-high-volume-thyroid-surgeon-serves-as-a-critical-first-step-toward-improving-organization-of-patient-care-and-training-around-thyroidectomy-at-a-regional-or-national-level%2C-potentially-bearing-significant-implications-regarding-qualityimprovement-initiatives%2C-identification-of-criteria-for-referral-and-payer-reimbursement%2C-and-surgical-education.-this-volume-threshold-is-also-important-for-patients-and-referring-physicians.-surgeons-are-generally-aware-of-how-many-procedures-they-perform-per-year%3B-in-addition%2C-with-maintenance-of-certification-and-recertification-requirements%2C-they-also-must-be-able-to-report-their-outcomes.-patients-should-be-able-to-ask-a-surgeon-directly-how-many-thyroidectomies-they-perform%2C-on-average%2C-per-year.-surgeons-have-an-ethical-responsibility-to-be-honest-and-report-their-own-case-numbers.-whereas-previous-attempts-at-implementation-of-high-volume-care-have-not-been-well-embraced-by-small-hospitals%2C-the-anticipated-departure-from-the-current-model-of-fee-for-service-to-value-based-reimbursement-may-shift-the-focus-to-volume-based-practice%2C-as-the-financial-risks-from-complications-will-be-imposed-on-hospitals.-in-areas-where-access-to-high-volume-surgeons-is-problematic%2C-providers-and-hospital-administrators-could-potentially-designate-a-surgeon(s)-to-perform-all-thyroidectomies-within-a-small-practice.-as-such%2C-these-data-potentially-have-important-implications-for-patients%2C-referring-providers%2C-surgeons%2C-hospitals%2C-and-payers. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/ti-rads-classification-had-great-diagnostic-value-in-diagnosing-thyroid-nodules.-the-actual-probability-of-malignancy-was-in-accord-with-the-theory-risk-of-malignancy.-in-summary%2C-the-ti-rads-proposed-by-kwak-has-reasonable-diagnostic-value-in-diagnosing-thyroid-nodules-for-malignancy.-the-actual-probability-of-malignancy-by-ti-rads-is-in-accord-with-the-theory-risk-of-malignancy. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/results%3A-these-clinical-guidelines-analyze-the-indications-for-thyroidectomy-as-well-as-its-definitions%2C-technique%2C-morbidity%2C-and-outcomes.-specific-topics-include-pathogenesis-and-epidemiology%2C-initial-evaluation%2C-imaging%2C-fine-needle-aspiration-biopsy-diagnosis%2C-molecular-testing%2C-indications%2C-extent-and-outcomes-of-surgery%2C-preoperative-care%2C-initial-thyroidectomy%2C-perioperative-tissue-diagnosis%2C-nodal-dissection%2C-concurrent-parathyroidectomy%2C-hyperthyroid-conditions%2C-goiter%2C-adjuncts-and-approaches-to-thyroidectomy%2C-laryngology%2C-familial-thyroid-cancer%2C-postoperative-care-and-complications%2C-cancer-management%2C-and-reoperation.-conclusions%3A-evidence-based-guidelines-were-created-to-assist-clinicians-in-the-optimal-surgical-management-of-thyroid-disease. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/the-4-commercially-available-molecular-tests-for-thyroid-cytology-offer-unique-approaches-to-improve-the-risk-stratification-of-thyroid-nodules.-familiarity-with-data-from-the-validation-studies-as-well-as-the-emerging-literature-about-test-performance-in-the-postvalidation-setting-can-help-users-to-select-and-interpret-these-tests-in-a-clinically-meaningful-way. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/results%3A-the-revised-guidelines-for-the-management-of-thyroid-nodules-include-recommendations-regarding-initial-evaluation%2C-clinical-and-ultrasound-criteria-for-fine-needle-aspiration-biopsy%2C-interpretation-of-fine-needle-aspiration-biopsy-results%2C-use-of-molecular-markers%2C-and-management-of-benign-thyroid-nodules.-recommendations-regarding-the-initial-management-of-thyroid-cancer-include-those-relating-to-screening-for-thyroid-cancer%2C-staging-and-risk-assessment%2C-surgical-management%2C-radioiodine-remnant-ablation-and-therapy%2C-and-thyrotropin-suppression-therapy-using-levothyroxine.-recommendations-related-to-long-term-management-of-differentiated-thyroid-cancer-include-those-related-to-surveillance-for-recurrent-disease-using-imaging-and-serum-thyroglobulin%2C-thyroid-hormone-therapy%2C-management-of-recurrent-and-metastatic-disease%2C-consideration-for-clinical-trials-and-targeted-therapy%2C-as-well-as-directions-for-future-research.-conclusions%3A-we-have-developed-evidence-based-recommendations-to-inform-clinical-decision-making-in-the-management-of-thyroid-nodules-and-differentiated-thyroid-cancer.-they-represent%2C-in-our-opinion%2C-contemporary-optimal-care-for-patients-with-these-disorders. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/thyroid-ablative-procedures-provide-valid-alternative-treatment-strategies-to-conventional-surgical-management-for-a-subset-of-patients-with-symptomatic-benign-thyroid-nodules.-careful-patient-and-nodule-selection-are-critical-to-the-success-of-these-procedures-as-is-extensive-pre-procedural-patient-counseling.-although-these-emerging-technologies-hold-great-promise%2C-they-are-not-without-risk-and-require-the-development-of-a-unique-skillset-and-environment-for-optimal%2C-safe-performance-and-consistent-outcomes. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/rfa-is-a-safe-and-effective-treatment-option-for-metastatic-cervical-lymph-node-recurrences-of-ptc-in-carefully-selected-patients-with-thyroid-cancer.-it-is-particularly-suitable-for-those-not-deemed-candidates-for-further-surgery-or-who-decline-further-surgical-intervention. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/after-1%3A1-matching%2C-each-group-had-49-elderly-patients.-the-rate-of-overall-complications-and-hypothyroidism-was-26.5%25-and-20.4%25-in-the-t-group%2C-respectively%2C-but-these-complications-were-totally-absent-from-the-r-group-(p%E2%80%89%3C%E2%80%89.001%2C-p-%3D-.001).-patients-in-the-r-group-had-a-significantly-shorter-procedural-time-(median%2C-4.8-versus-95.0-minutes%2C-p%E2%80%89%3C%E2%80%89.001)-and-lower-cost-(us-%241979.02-versus-us-%242208.80%2C-p-%3D-.013)-than-those-treated-by-thyroidectomy.-after-radiofrequency-ablation%2C-the-volume-reduction-rate-was-94.1%25%2C-and-12.2%25-of-nodules-had-completely-disappeared.-the-symptom-and-cosmetic-scores-were-both-significantly-reduced-at-the-last-follow-up.-conclusions%3A-radiofrequency-ablation-could-be-considered-as-a-first-line-treatment-for-elderly-patients-with-benign-thyroid-nodules.-suggestion%3A-download-the-full-article-to-include-in-insurance-appeal-documents 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/this-therapy-will-save-the-patient-and-the-entire-healthcare-system-a-considerable-amount-of-money.-as-the-healthcare-community-and-patients-continue-to-advocate-for-this-non-surgical-solution-of-benign-thyroid-nodules%2C-the-availability-to-utilize-insurance-healthcare-benefits-will-increase. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/as-ultrasound-guided-ablation-procedures-are-increasingly-utilized-in-benign-and-malignant-thyroid-disease%2C-evidence-based-and-thoughtful-application-of-best-practices-is-warranted. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/rfa-achieved-a-significantly-larger-nodule-volume-reduction-at-12-months%3B-however%2C-the-technical-success-rate-was-similar-in-the-rfa-and-la-groups. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/rfa-is-a-safe-and-efficacious-treatment-for-symptomatic-nftns-and-aftns-in-our-population-and-is-especially-effective-for-smaller-nodules.-rfa-should-be-considered-an-alternative-for-tns-in-patients-who-cannot-or-do-not-want-to-undergo-surgery. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/a-total-of-233-nodules-were-included.-the-median-and-interquartile-range-of-volume-reduction-rate-(vrr)-at-1%2C-3%2C-6%2C-and-12-months-were-54%25-%5Binterquartile-range-(iqr)%3A-36%25%E2%80%9373%25%5D%2C-58%25-(iqr%3A-37%25%E2%80%9380%25)%2C-73%25-(iqr%3A-51%25%E2%80%9390%25)%2C-and-76%25-(iqr%3A-52%25%E2%80%9390%25)%2C-respectively-(p%3C0.001).-four-patients-presented-with-toxic-adenomas.-all-patients-were-confirmed-euthyroid-at-3-month-postprocedure-follow-up.-two-patients-developed-temporary-hoarseness-of-voice%2C-but-no-hematoma-or-nodular-rupture-occurred-postprocedure.-elastography-was-significantly-associated-with-vrr.-compared-with-soft-nodules%2C-stiff-nodules-were-more-likely-to-have-a-lower-vrr-(odds-ratio%3A-11.64%2C-95%25-confidence-interval%3A-3.81%E2%80%9335.53%2C-p%3C0.05)%2C-and-mixed-elasticity-was-also-more-likely-to-have-a-lower-vrr-(odds-ratio%3A-4.9%3B-95%25-confidence-interval%3A-1.62%E2%80%9314.85%2C-p%3C0.05).-conclusions%3A-this-is-the-largest-multi-institutional-north-american-study-examining-thyroid-nodule-treatment-response-to-rfa.-rfa-is-a-safe-and-effective-treatment-option-that-allows-preservation-of-thyroid-function-with-minimal-risk-of-procedural-complications. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/in-conclusion%2C-rfa-appears-to-be-a-safer-alternative-to-surgery-for-benign-thyroid-nodules%2C-especially-in-patients-who-are-high-risk-surgical-candidates.-however%2C-randomized-trials-with-longer-follow%E2%80%90up-of-at-least-5%E2%80%89years-are-needed-in-north-american-population%2C-which-will-help-to-formulate-a-surveillance-protocol. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/thyroid-rfa%2C-following-trends-in-asia-and-europe%2C-is-emerging-in-the-united-states-as-a-minimally-invasive-treatment-for-certain-thyroid-conditions.-while-more-long-term-data-are-needed%2C-initial-results-suggest-that-thyroid-rfa-is-a-safe-and-highly-effective-treatment-for-the-non-surgical-treatment-of-the-symptomatic%2C-benign%2C-nonfunctional-thyroid-nodules. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/rfa-can-be-an-alternative-treatment-modality-in-the-management-of-benign-symptomatic-thyroid-nodules.-the-results-showed-that-it-is-a-safe-and-effective-procedure.-rf-ablation-can-be-an-alternative-treatment-modality-in-the-management-of-symptomatic-benign-solid-thyroid-nodules-in-properly-selected-patients.-our-study-showed-that-rfa-improves-symptoms-and-is-effective-on-volume-reduction-in-patients-with-biopsy-proven-benign-solid-thyroid-nodules.-the-procedure-caused-minor-side-effects-like-pain-in-a-few-patients%2C-and-this-was-easily-managed-and-no-other-major-complications-occurred. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/radiofrequency-ablation-(rfa)-for-thyroid-nodules-is-a-classic-example-of-a-medical-innovation-that-takes-an-existing-technology-and-applies-it-to-a-new-indication.-rfa-has-all-the-attributes-to-be-successfully-adopted-and-diffuse-into-society.-us-physicians-are-%22early-adopters%22-and-will-make-a-significant-contribution-to-help-surpass-%E2%80%9Ctipping-point%E2%80%9D-for-rfa-of-thyroid-nodules-and-ensure-successful-widespread-diffusion-of-innovation. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/radiofrequency-ablation-(rfa)-is-a-minimally-invasive-technique-that-has-been-used-to-treat-benign-and-malignant-tumors-%5B21%E2%80%9324%5D.-in-the-thyroid-gland%2C-rfa-has-been-applied-to-a-recurrent-thyroid-cancer-%5B23%5D-and-benign-thyroid-nodules-%5B25%5D.-this-study-evaluated-the-safety-and-effectiveness-of-rfa-at-reducing-volume-in-benign-thyroid-nodules.-in-conclusion%2C-rfa-is-a-safe-modality-effective-at-reducing-volume-in-benign-thyroid-nodules.-thyroid-nodule-rfa-appears-safe-and-imaging-follow-up-confirms-volume-reduction. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/an-interdisciplinary-statement-from-the-following-professional-associations%3A-austrian-thyroid-association-(%C3%B6sdg)%2C-austrian-society-for-nuclear-medicine-and-molecular-imaging-(ognmb)%2C-austrian-society-for-endocrinology-and-metabolism-(%C3%B6ges)%2C-surgical-endocrinology-working-group-(ace)-of-the-austrian-surgical-society-(oegch) 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/radiofrequency-(rf)-induces-thermal-injury-into-the-target-lesion-by-means-of-an-alternating-electric-field%2C-produced-by-an-electrode-needle-connected-to-an-external-radiofrequency-generator.-tissue-necrosis-is-achieved-around-the-needle-tip%2C-through-the-heating-induced-by-rapid-ion-movement%2C-in-a-controlled-fashion.-first-rf-ablation-studies-on-thyroid-nodules-were-performed-with-a-17-gauge-internally-cooled-electrode-needle-%5B19%E2%80%9321%5D-or-with-a-14-gauge-device%2C-equipped-with-expandable-hooks-to-obtain-a-more-extended-ablation-area-%5B22%E2%80%9324%5D.-after-local-anesthesia%2C-the-needle-is-inserted-into-the-target-nodule-through-a-small-incision.-the-application-of-rf-energy-requires-several-minutes-to-produce-tissue-necrosis%2C-without-moving-the-needle-(%E2%80%9Cfixed-electrode-procedure%E2%80%9D).-when-the-ablation-area-is-obtained%2C-the-needle-can-be-removed-or-relocated-in-a-different-part-of-the-lesion%2C-if-necessary%2C-to-complete-the-ablation-treatment.-radiofrequency-ablation-and-other-nonsurgical%2C-minimally-invasive%2C-us-guided-techniques-may-play-an-important-role-in-the-management-of-nodular-thyroid-disease-today-and-in-future-clinical-practice.-this-statement-was-made-to-clarify-this-role-and-to-make-it-consistent-in-italian-centers-for-thyroid-disease.-focusing-on-radiofrequency-thermal-ablation-after-a-comprehensive-evaluation-of-pieces-of-scientific-evidence-and-experts%E2%80%99-opinions-and-suggestions%2C-the-panel-approved-several-indications-for-this-technique-in-thyroid-pathology%2C-with-complete-or-partial-agreement-among-experts%2C-trying-to-define-the-most-appropriate-treatment-in-different-clinical-conditions. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/in-2016%2C-the-american-association-of-clinical-endocrinologists%2C-american-college-of-endocrinology%2C-and-associazione-medici-endocrinologi-published-medical-guidelines-for-clinical-practice-for-the-diagnosis-and-management-of-thyroid-nodules.-the-guidelines-cover-diagnostic-and-therapeutic-aspects-of-thyroid-nodular-disease-and-consider-rfa-for-the-treatment-of-solid-or-complex-thyroid-nodules-that-progressively-enlarge%2C-are-symptomatic-or-cause-cosmetic-concern.-they-indicate-that-the-procedure-%E2%80%9Cmay-offer-a-less-expensive-and-less-invasive-alternative-to-thyroid-surgery%2C-without-the-risks-of-subsequent-cutaneous-scar-or-hypothyroidism%2C-for-patients-with-steadily-growing-benign-thyroid-nodules-who-warrant-treatment-for-cosmetic-reasons-or-local-symptoms. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/ultrasound-is-a-widely-used-method-for-guiding-and-monitoring-rfa-of-the-thyroid-gland.-there-is-no-risk-of-radiation-exposure%2C-and-it-is-possible-to-evaluate-the-thyroid-gland-and-to-examine-cervical-lymph-nodes-(14%2C23%2C26).-however%2C-thyroid-nodules-are-common-in-asymptomatic-persons%3B-therefore%2C-rfa-should-be-performed-according-to-the-indications-of-guidelines.-acceptability-and-applicability-thyroid-rfa-should-be-performed-with-well-trained-thyroid-rfa-experts-and-facilities-(12).-thyroid-rfa-was-chosen-as-the-treatment-method-for-patients-with-benign-thyroid-nodules-and-recurrent-thyroid-cancers-in-several-medical-guidelines-(23%2C24).-as-a-result-of-the-evaluation-of-domestic-acceptability-and-applicability-of-these-guidelines%2C-it-was-concluded-that-the-applicability-of-rfa-to-treat-thyroid-lesions-is-reasonable. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/benefits-the-evidence-that-nice-looked-at-for-ultrasound%E2%80%91guided-percutaneous-radiofrequency-ablation-to-treat-thyroid-nodules-showed-that-the-procedure-was-safe-enough-and-worked-well-enough-to-be-used-in-the-nhs.-the-7-studies-that-nice-looked-at-involved-about-2%2C500-patients.-generally%2C-they-showed-the-following-benefits%3A-nodules-were-smaller-some-patients-were-able-to-reduce-or-stop-taking-drugs-for-overactive-thyroid-(hyperthyroidism)-cosmetic-appearance-was-better-and-most-people-had-less-severe-symptoms-after-the-procedure. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/guidelines-for-the-interventional-procedure-of-rfa-are-available-from-the-united-kingdom-and-korea.-they-were-compiled-by-experts-in-the-fields-of-thyroidology%2C-endocrinology%2C-interventional-radiology%2C-and-surgery.-the-guidelines-provide-recommendations-for-rfa-treatment-of-benign-thyroid-nodules%3B-they-are-informed-by-a-systematic-review-of-evidence-and-an-assessment-of-the-benefits-and-harms-of-alternative-treatment-options.-medical-guidelines-from-the-american-association-of-clinical-endocrinologists%2C-american-college-of-endocrinology%2C-and-associazione-medici-endocrinologi-(italy)-for-the-management-of-thyroid-nodules-include-rfa-as-a-treatment.-please-read-these-guidelines-for-a-complete-overview-of-the-available-data-supporting-the-use-of-rfa-for-the-treatment-of-benign-thyroid-nodules.-in-november-2015%2C-and-updated-in-april-2016%2C-the-national-institute-for-health-and-care-excellence-(nice)%2C-u.k.-prepared-an-interventional-procedure-overview-based-on-a-rapid-review-of-the-medical-literature-and-specialist-opinion.-the-overview-is-based-on-approximately-2500-patients-from-studies-and-reviews-that-are-relevant-to-ultrasound-guided-percutaneous-rfa-for-thyroid-nodules. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/nowadays%2C-available-reports-of-application-of-rfa-in-benign-thyroid-nodules-were-mainly-from-two-centers.-the-main-weaknesses-of-using-rfa-on-the-thyroid-gland-are-several-folds-and-they-include-the-lack-of-definitive-histology%2C-possibility-of-incomplete-nodule-ablation%2C-and-surveillance-problems-for-the-residual-thyroid-mass-after-rfa.-however%2C-rfa-appears-to-be-an-effective-nonsurgical-option-to-improve-pressure-and-toxic-symptoms-in-biopsy-proven-benign-thyroid-nodules.-preliminary-reports-showed-satisfactory-results-in-volume-reduction%2C-pressure-symptoms%2C-and-cosmetic-symptoms%2C-and-these-results-appear-to-be-sustained-in-the-long-term.-therefore%2C-proper-selection-of-patient-with-benign-nodule-for-rfa-and-subsequent-monitoring-were-needed. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/at-six-months%2C-btn-volume-significantly-decreased-in-group-a-(15.1-%E2%80%93-3.1-ml-vs.-4.2-%E2%80%93-2.7-ml%3B-p-%3C-0.0001)%2C-whereas-it-remained-unchanged-in-group-b-(14.4-%E2%80%93-3.3-ml-vs.-15.2-%E2%80%93-3.5-ml).-the-baseline-volume-was-larger-in-the-italian-series-(16.4-%E2%80%93-2.5-ml-vs.-13.9-%E2%80%93-3.3-ml%2C-p-%3D-0.009).-however%2C-at-six-months%2C-there-was-no-significant-difference-between-the-korean-group-and-the-italian-group-(3.7-%E2%80%93-2.9-ml-vs.-5.5-%E2%80%93-2.2-ml).-both-cosmetic-and-compressive-symptoms-significantly-improved-(3.6-%E2%80%93-0.5-vs.-1.7-%E2%80%93-0.4-and-3.6-%E2%80%93-1.9-vs.-0.4-%E2%80%93-0.7%2C-respectively%3B-p-%3C-0.001).-no-side-effects-occurred.-conclusions%3A-rfa-was-effective-in-reducing-the-volume-of-btn.-the-outcome-was-similar-in-centers-with-different-experience-in-the-moving-shot-technique. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/in-summary%2C-by-pooling-of-these-studies-we-recommended-that-rfa-indeed-has-the-advantages-in-improving-outcomes-and-providing-better-prognosis-for-patients-with-benign-tns. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/rfa-reduced-nodular-volume-by-70%25-after-6-months%2C-84%25-after-36-months-and-it-was-an-effective-method-for-treating-nodule-related-clinical-problems-and-hot-nodules.-47-(10.4%25)-patients-with-big-nodule-volume-underwent-2%E2%80%936-sessions-of-rfa.-cosmetic-results-were-excellent-in-96%25-of-patients-in-the-rfa-group.-no-serious-complications-such-as-thyroiditis%2C-voice-change%2C-and-hematomas-were-observed-in-rfa-patients.-conclusion%3A-rfa-was-effective-and-safe-for-treating-benign-thyroid-nodules.-rfa-might-be-recommended-for-treating-benign-thyroid-nodules-as-the-first-line-treatment. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/rfa%2C-mwa-and-hifu-showed-comparable-results-considering-volume-reduction.-all-methods-are-safe-and-effective-treatments-of-benign-thyroid-nodules.-key-points-%E2%80%A2-thermal-ablation-can-be-used-to-treat-benign-thyroid-nodules-%E2%80%A2-thermal-ablation-can-be-an-alternative-to-thyroidectomy-or-radioiodine-therapy-%E2%80%A2-radiofrequency-ablation%2C-microwave-ablation%2C-high-intensity-focused-ultrasound-are-safe-and-effective 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/nodule-shrinkage-was-also-accompanied-by-an-improvement-in-cosmetic-and-symptom-scores.-prior-to-rfa%2C-62.8%25-of-the-patients-had-a-nodule-that-was-visible-with-or-without-neck-extension.-at-three-months-post-rfa%2C-this-percentage-decreased-to-17.1%25%2C-and-at-12-months%2C-it-decreased-to-7.1%25-(p%E2%80%89%3C%E2%80%890.001).-the-difference-between-3-and-12-months-was-also-significant-(p%E2%80%89%3C%E2%80%890.001).-patients-with-a-symptom-score-of-%E2%89%A53-(52.9%25)-or-%E2%89%A54-(38.2%25)-at-baseline-also-reported-improvements-at-month-3-(5.2%25-and-1%25-with-symptom-score-%E2%89%A53-or-%E2%89%A54)-and-at-month-12-(2.8%25-and-0%25)-after-rfa.-this-difference-between-the-scores-at-3-and-12-months-was-also-significant-(p%E2%80%89%3C%E2%80%890.001).-the-most-important-outcomes%2C-however%2C-are-the-absolute-decrease-in-the-percentage-of-patients-with-significant-symptoms-(vas-%E2%89%A54)-from-38.2%25-to-0%25%2C-and-the-reduction-in-the-number-of-%E2%80%9Cvisible%E2%80%9D-nodules-from-62.8%25-to-7.5%25-one-year-post-rfa.-it-is-not-surprising-that-practically-all-other-studies-have-also-reported-improvements-in-symptoms-and-cosmetic-scores%2C-since-they-also-reported-marked-volume-effects-by-rfa-(18%2C23).-however%2C-a-weak-correlation-is-often-observed-between-nodule-size-and-the-degree-of-symptoms%2C-that-is%2C-patients-with-easily-visible-nodules-frequently-experience-almost-no-symptoms%2C-while-others-with-nodules-a-few-milliliters-in-size-complain-of-overt-symptoms.-in-the-authors'-view%2C-this-phenomenon%2C-which-is-likely-dependent-on-neck-anatomy%2C-nodule-topography-and-composition%2C-pain-threshold%2C-cultural-attributes%2C-as-well-as-other-factors-(24)%2C-should-be-considered-in-data-analyses.-therefore%2C-such-data-are-presented-broken-down-into-%E2%80%9Ccategories%E2%80%9D-of-a-symptom-and-a-cosmetic-score-rather-than-as-an-%E2%80%9Caveraged-number%E2%80%9D-for-the-entire-group.-it-is-concluded-that-a-single-treatment-course-with-monopolar-radiofrequency-ablation-is-both-safe-and-highly-effective-in-terms-of-nodule-volume-reduction%2C-relief-of-local-symptoms%2C-and-(in-patients-with-hyperthyroidism)-restoration-of-euthyroid-function.-in-no-case-was-a-prescription-of-thyroid-medication-required-among-those-patients-who-were-euthyroid-at-baseline. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/in-this-population%2C-rfa-of-benign-large-tns-performed-similarly-to-the-reports-from-europe-and-asia.-it-induces-a-substantial-volume-reduction-of-predominantly-solid-tns%2C-improves-compressive-symptoms-and-cosmetic-concerns%2C-and-does-not-affect-normal-thyroid-function.-radiofrequency-ablation-has-an-acceptable-safety-profile-and-should-be-considered-as-a-low-risk-alternative-to-conventional-treatment-of-symptomatic-benign-tns.-the-present-experience-confirms-that-ultrasound-guided-rfa-is-a-clinically-effective-and-safe-outpatient-treatment-in-patients-with-symptomatic-or-steadily-growing-benign%2C-large%2C-predominantly-solid-tns%2C-reproducing-the-experience-generated-in-european-and-asian-studies.-this-procedure-induces-substantial-volume-reduction-of-tns-by-approximately-45%25-at-3-to-6-months%2C-alleviates-compressive-symptoms%2C-and-improves-aesthetic-appearance-while-preserving-normal-thyroid-function.-in-centers-with-appropriate-expertise%2C-this-technique-could-become-an-alternative-for-the-management-of-benign-large-toxic-and-nontoxic-tns.-additional-studies-should-be-conducted-in-similar-populations%2C-with-particular-focus-on-factors-predicting-greater-response-to-rfa%2C-comparing-the-performance-of-rfa-with-other-procedures%2C-and-timing-of-the-additional-rfa-sessions. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/based-on-the-existing-literature%2C-the-greatest-shift-in-the-future-routine-management-of-benign-thyroid-nodules-will-probably-be-determined-by-the-availability-of-nonsurgical%2C-minimally-invasive-techniques%2C-such-as-rfa.-this-technique-has-shown-the-potential-to-help-in-the-daily-management-of-thyroid-nodules%2C-particularly-when-they-are-single%2C-cold%2C-and-symptomatic%2C-where-it-has-been-proven-safe-and-effective.-in-our-view%2C-rfa-does-not-overlap-with-the-conventional-and-established-treatments-for-thyroid-nodules%2C-namely-surgery-and-radioiodine%2C-but-it-is-complementary-to-them.-rfa-could-in-fact-represent-the-solution-for-a-need-that-has-remained-unanswered-for-years%2C-helping-those-patients-that-perceive-their-nodule-as-s-something-too-small-to-be-conventionally-treated-(or-which-cannot-be-conventionally-treated)%2C-but-too-big-to-keep-with-the-simple-clinical-follow-up. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/the-evaluation-and-management-of-patients-with-thyroid-nodules-is-no-longer-a-1-size-fits-all-proposition.-the-tailored-approach-advocated-today-requires-a-careful-assessment-of-each-nodule-to-determine-the-likelihood-that-it-is-malignant-and-the-chances-that-it-will-cause-symptoms.-very-few-nodules-will-require-an-intensive-workup-that-includes-cytology-and-molecular-testing-of-fnab-samples%3A-for-the-vast-majority%2C-a-systematic-cervical-us-examination-with-assessment-of-clinical-risk-factors-will-provide-a-reliable-foundation-for-identifying-the-initial-management-strategy.-after-an-appropriate-initial-assessment%2C-the-frequency-of-subsequent-surveillance-visits-for-most-nodules-can-be-safely-reduced-compared-with-currently-used-schedules.-this-is-particularly-relevant-for-frail%2C-elderly-individuals%2C-as-they-are-unlikely-to-be-harmed-by-the-thyroid-tumor-itself%2C-and-overmedicalization-can-cause-more-harm-than-good.-in-these-populations%2C-surveillance-can-safely-be-confined-to-a-periodic-clinical-examination.-if-surgery-is-needed%2C-resections-can-often-be-less-extensive.-in-some-cases%2C-minimally-invasive%2C-percutaneous-approaches-are-a-viable-alternative-to-surgery.-when-there-are-multiple-options%2C-they-should-be-discussed-as-frankly-as-possible-with-the-patient%2C-outlining-the-advantages%2C-limitations%2C-benefits%2C-and-risks-of-each.-the-goal-is-to-identify-the-best-strategy-for-the-individual-patient%2C-in-terms-of-disease-outcomes-and-quality-of-life%2C-avoiding-the-pitfalls-of-overdiagnosis-and-overtreatment.-for-health-professionals%2C-this-means-learning-to-work-with-some-degree-of-clinical-uncertainty-rather-than-automatically-resorting-to-intensive-testing-and-intervention%2C-and-by-weighing-patients%E2%80%99-expectations-and-demands. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/a-short-discussion-concerning-the-tolerability-of-rfa-should-be-addressed.-rfa-has-been-reported-as-safe-and-well-tolerated-procedure.-in-fact%2C-a-recent-systematic-review-found-an-overall-complication-rate-of-2.38%25-and-major-complications-were-recorded-in-1.35%25.-no-patients-had-any-lifethreatening-rfa-related-complications-%5B30%5D.-then%2C-in-2017-korean-guidelines-the-panel-quoted-that-thyroid-rfa-is-associated-with-a-low-incidence-of-complications-when-performed-by-experienced-operators-(strong-recommendation%2C-high-quality-evidence)-%5B9%5D.-this-issue-should-encourage-to-use-rfa-also-in-aftn%2Fttn 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/based-on-current-findings%2C-the-selection-of-nodules-for-pre-treatment-allows-for-better-long-term-responses%2C-especially-for-nodules-with-a-lower-pre-treatment-volume-(%E2%89%A422.4-ml)-and%2For-a-macrocystic-echostructure%3B-early-shrinkage-of-the-nodule%2C-as-observed-by-a-vrr1m-%E2%89%A550%25-at-one-month-follow-up%2C-is-shown-to-be-a-good-predictor-of-positive-rfa-responses.-therefore%2C-these-factors-represent-the-best-positive-predictors-of-the-radiofrequency-thermal-ablation-technique-on-benign-thyroid-nodules.-in-conclusion%2C-these-parameters-should-always-be-evaluated-before-considering-any-treatment-with-rfa-to-estimate-the-probability-of-success-or-failure-of-the-therapeutic-method-that-is-targeted-for-each-case.-this-result-has-important-implications-from-a-clinical-point-of-view%3A-(i)-patients-can-be-made-more-confident-on-the-resolution-of-reported-symptoms%2C-and-(ii)-it-provides-a-valid-alternative-to-the-surgical-approach-while-permitting-to-gain-relevant-information-on-the-need-of-repeated-treatment-sessions%2C-if-these-factors-are-absent. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/all-the-studies-under-examination-consistently-validated-the-long-term-clinical-efficacy-and-the-substantial-safety-of-rfa-for-the-treatment-of-benign-thyroid-nodules.-thermal-ablation%2C-however%2C-is-an-operator-dependent-technique-and-should-be-performed-in-centers-with-specific-expertise.-the-selection-of-the-patients-should-be-rigorous-because-the-nodule-size-and-the-structural-and-functional-characteristics-influence-the-appropriateness-and-the-outcomes-of-the-treatment.-future-perspectives-as-the-treatment-of-micro-papillary-thyroid-cancer-or-cervical-recurrence-need-further-investigations. 2026-02-09 https://www.thyroidnoduletreatment.center/es/research/thermal-ablations-are-safe-and-effective-methods-for-treating-benign-thyroid-nodules%2C-as-shown-by-a-long-follow-up-analysis-of-more-than-3-years.-in-addition%2C-rfa-showed-superior-vrrs-compared-with-la-for-the-treatment-of-benign-thyroid-nodules%2C-with-less-regrowth-and-less-delayed-surgery. 2026-02-09