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Radiofrequency Ablation for Thyroid Nodules (RATED Study)—Analysis of a Learning Curve and Predictors of Success

Radiofrequency ablation (RFA) is used as treatment for symptomatic thyroid nodules. Factors influencing the volume reduction ratio (VRR) at 12 months are not yet fully understood. The primary objective of this work was evaluating the VRR at 12 months after RFA. Secondary objectives were the assessment of a learning curve and factors influencing the VRR at 12 months.

Manon M D van der Meeren, Tim Boers, Pim de Graaf, Katya M Duvivier, Koen M A Dreijerink, Laura N Deden, Peter Veendrick, Paul Cernohorsky, Frank B M Joosten, Angelique B M C Savelberg, Sicco J Braak, Sean H P P Roerink, Michel Versluis, Srirang Manohar, Wim J G Oyen, Radiofrequency Ablation for Thyroid Nodules (RATED Study)—Analysis of a Learning Curve and Predictors of Success, The Journal of Clinical Endocrinology & Metabolism, Volume 110, Issue 11, November 2025, Pages 3201–3209, https://doi.org/10.1210/clinem/dgaf058

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In RFA for thyroid nodules, a stable treatment efficacy is achieved after 20 treatments, with a median VRR of 70.8%. Baseline nodule volume, energy delivered, and prolonged follow-up 6 months after treatment may not be clinically relevant to predict treatment success.

thyroid, radiofrequency ablation, nodule, learning curve, ultrasound

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